Recombinant Cardiac ATP-Sensitive Potassium Channels and Cardioprotection
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چکیده
منابع مشابه
Recombinant cardiac ATP-sensitive potassium channels and cardioprotection.
The ATP-dependent potassium channels (KATP channels) were originally identified in isolated membrane patches prepared from guinea pig ventricular myocytes by Noma in 1983. Since their discovery in cardiac cells, KATP channels have also been discovered in many other tissues, such as smooth muscle, skeletal muscle, pancreas, and brain, in which they have been shown to couple cellular metabolism t...
متن کاملATP-sensitive potassium channels: metabolic sensing and cardioprotection.
The cardiovascular system operates under a wide scale of demands, ranging from conditions of rest to extreme stress. How the heart muscle matches rates of ATP production with utilization is an area of active investigation. ATP-sensitive potassium (K(ATP)) channels serve a critical role in the orchestration of myocardial energetic well-being. K(ATP) channel heteromultimers consist of inwardly-re...
متن کاملCardiovascular ATP-sensitive potassium channels
Sulfonylurea drugs stimulate endogenous insulin secretion by blockade of ATP-sensitive potassium channels in pancreatic beta cells. These drugs are widely used in the treatment of type 2 diabetes. However, as ATP-sensitive potassium channels also exist in cardiomyocytes and coronary and peripheral arterial vascular smooth muscle cells, sulfonylurea drug usage in theory may cause unwanted cardio...
متن کاملEndothelial biology and ATP-sensitive potassium channels
ATP sensitive potassium (KATP) channels are metabolic sensors with channel activity promoted by decreases in ATP andnor increases in MgADP. The most studied are channels present in cardiac myocytes and pancreatic b cells but KATP currents also exist more widely in a range of tissues and organs [1,2]. The channel is a hetero-octamer comprising four sulphonylurea receptors and four pore-forming i...
متن کاملATP-sensitive Potassium Channels and L-type Calcium Channels are Involved in Morphine-induced Hyperalgesia after Nociceptive Sensitization in Mice
Introduction: We investigated the role of ATP-sensitive potassium channels and L-type calcium channels in morphine-induced hyperalgesia after nociceptive sensitization. Methods: We used a hotplate apparatus to assess pain behavior in male NMRI mice. Nociceptive sensitization was induced by three days injection of morphine and five days of drug free. On day 9 of the schedule, pain behavior te...
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ژورنال
عنوان ژورنال: Circulation
سال: 1998
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.98.15.1479